Development And Evaluation Of Polymeric Chitosan Composites Mucoadhesive Films Containing Benzocaine For Treatment Of Oral Disease

Abstract

A buccal mucoadhesive Benzocaine local delivery system was the focus of the current study's optimisation and evaluation efforts. To determine how much chitosan and HPMC was used, a full 3² factorial design was used to assess the effects on buccal film properties. The results demonstrated that PVP concentration had a large synergistic effect on film swelling whereas chitosan just minimally and insignificantly slowed film swelling. Moreover, chitosan's agonistic influence on mechanical film characteristics was the only one that was notable.  Additionally, HPMC dramatically increased the Higuchi diffusion slope of the drug release from buccal films, whereas chitosan blocked this effect. For buccal films, the optimised recipe demonstrated sufficient mechanical characteristics. This study showed that the improved Benzocaine mucoadhesive buccal film is a superior alternative dose form and can help patients avoid the unintended side effects of the medication.