Radiatus Leaf Extracts Pharmacological Studies For Anxiolytics And Analgesic Activity

Abstract

The Malvaceae family includes the shrub Hibiscus radiatus. Known by another name, monarch rose mallow, it's a crop that grows easily in multi-cropping systems and is useful for both food and fibre, making it a perfect crop for impoverished nations. The plant is used to prepare liquid concoctions and is said to be a blood purifier and fever treatment. All of its parts are chopped and cooked. The chemical components that may be in charge of the biological activities7 include alkaloids, glycosides, phenolic compounds, steroids, sterols, tannins, saponins, flavones, and flavonoids as well as proteins, amino acids, and carbohydrates. OECD guideline No.425 of CPCSEA was adopted for acute toxicity studies. The antiulcer activity of different extracts of Hibiscus radiatus was investigated by employing two models i,e. pyloric ligation method and ethanol induced ulcer model by using rats, Omeprazole was taken as standard drug. The raised plus maze model and the light and dark paradigm both demonstrated anxiolytic activity, with diazepam being used as the usual medication. One may argue that there has been noticeable activity in every extract. The extract with the most notable anxiolytic action among the others is the Hibiscus radiatus aqueous extract. The acetic acid writhing model and the hot plate model were used to test the analgesic activity, and diclofenac sodium was administered as prescribed. Aqueous extract of Hibiscus radiatus has demonstrated a highly substantial analgesic efficacy among the extracts, all of which have demonstrated considerable action. According to this study, Hibiscus radiatus leaf extracts have demonstrated strong analgesic, anxiolytic properties.