Preparation And Evaluation Of -Cyclodextrin Inclusion Complexes Of Cefpodoxime Proxetil.

Abstract

Cefpodoxime proxetil, a third-generation cephalosporin antibiotic used in the treatment of various diseases like respiratory tract infection, urinary tract infection.  Due to its low aqueous solubility, it has reported 40–50% oral bioavailability. In the present research work, Cefpodoxime proxetil inclusion complexes were prepared with b-cyclodextrin in different molar ratios employing two different methods.  The solubility data shows that an increased aqueous solubility of Cefpodoxime proxetil when formulated as an inclusion complex when compared with plain pure drug Cefpodoxime proxetil and also increased concentration of cyclodextrins, increases the solubility of Cefpodoxime proxetil.

Interaction between the drug and polymer was assessed by IR, and DSC thermogram provided strong evidence. The in vitro release study of Cefpodoxime proxetil inclusion complexes were carried out in 6.8 pH phosphate buffer as dissolution media.

The inclusion complexes prepared with b-cyclodextrin showed better release when compared with inclusion complexes prepared by various methods. Among the two methods, release rate was better with complexes prepared by kneading method in comparison to physical mixture method.

The formulations BF₃A i.e. Cefpodoxime proxetil b-cyclodextrin inclusion complex (1:3 molar ratio) prepared by kneading method showed better T70 (16 minutes) and T90 (22.5 minutes) values.

Cefpodoxime proxetil's response was enhanced by increasing its water solubility and dissolution rate by inclusion complex formulation with cyclodextrins.