In- Vitro Anticancer Activity Of Mimosa Hamata Against A549, PA-1 And KB-3-1 Cell Lines And HPTLC Studies Of Mimosa Hamata

Abstract

The study explores the cytotoxic potential of the ethanol extract of plant Mimosa hamata against various cancer cell lines using the MTT assay. The extract demonstrated moderate cytotoxicity with IC50 values of 205.75 ± 3.38 µg/ml for A549 lung cancer.cells and 153.12 ± 2.33 µg/ml for PA-1 ovarian cancer cells. Notably, it exhibited the highest efficacy against KB-3-1 oral cancer cells, achieving an IC50 of 125.60 ± 2.04 µg/ml, indicating strong potential as an anti-cancer treatment, particularly for oral cancer. Additionally, high-performance thin-layer chromatography (HPTLC) fingerprinting revealed seven distinct bands in the extract, with a significant peak at Rf 0.43, likely attributable to quercetin. The presence of quercetin, along with other phytochemicals, suggests a multifaceted mechanism of action contributing to the extract's cytotoxic effects.  These findings highlight the promise of the ethanol extract of Mimosa hamata as a viable candidate for cancer therapy and underscore the need for further investigations into its therapeutic mechanisms and clinical applications.