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As everyone is aware, spices have always played a significant role in human meals and trade, particularly in India. Recent general acceptance of the connections between nutrition and health strengthens the significance of diet. It is a firm belief that plant therapy offers protection since it is risk-free and natural, offering an alternative to manmade medications. As the globe experiences a Renaissance, herbal treatments are once more on display. Numerous recent studies from the US and Europe have verified that within a few years, the use of herbal treatment for hepatic illnesses would soar by up to 65 percent. The reality is that regular use of hepato-protective medications is clearly insufficient, and in recent decades, research into the use of natural herbal remedies has increased. Due to their therapeutic potential for a variety of diseases, the bioactive components they contain are of great value. They frequently fall under the category of functional meals since they provide physiological advantages or prevent chronic illnesses in addition to providing basic nourishment. Due to its anti-oxidant, anti-microbial, and gastro-protective components, black pepper (Piper Nigrum L.) is a significant healthy food. Piperine, the active component in black pepper, is part of a complex phytochemistry that also contains volatile oil, oleoresins, and alkaloids.It may have a part to play in non-alcoholic fatty liver disease, according to several research. As it encompasses a range of liver abnormalities, from a simple non-alcoholic fatty liver (NAFL, simple fatty liver disease) to more advanced ones like non-alcoholic steatohepatitis (NASH), cirrhosis, and even liver cancer, NAFLD, the abnormal accumulation of fat in the liver in the absence of secondary causes of fatty liver, such as harmful alcohol use, viral hepatitis, or medications, is a serious health concern. The worldwide burden of NASH has more than quadrupled during the past 20 years. 94 lakh cases of compensated cirrhosis were caused by NASH globally in 2017, up from 40 lakh cases in 1990. In India, NAFLD is becoming a significant contributor to liver disease.