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Mixed connective tissue disorder (MCTD) is a rare autoimmune clinical entity with features of an overlapping syndrome, including systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, polymyositis, and dermatomyositis. The annual incidence of mixed connective tissue disorder (MCTD) was 1.9 per 10,000 population. In this study we described the progonosis, clinical features, treatment of mixed Connective tissue disorder with systemic lupus erythematous of three patients in a clinical center of Hyderabad. It should be of great interest to internal medicine and rheumatology diagnosticians. A long-term treatment and management plan is crucial for patients with mixed connective tissue disorders (MCTD). Based on our study we concluded that, patient’s condition got better by prescribing corticosteroid therapy.