Potential Use of Tembelekan Leaf Plant Extract (Lantana camara linn) on Hematological and Histopathological Profiles of Goldfish (Cyprinus carpio) infected with Edwardsiella tarda Bacteria

Abstract

The purpose of this study was to analyze the hematological and histopathological features of carp (C. carpio) gills treated with the active compound of Tembelekan leaf extract (L. camara Linn). The method used in this research is Completely Randomized Design (CRD). The treatment used in this study was treatment A (50 mg/L), B (100 mg/L), C (150 mg/L), D (200 mg/L), E (250 mg/L), negative control (healthy fish), and positive control (Tetracycline antibiotics). The results of haematological and histopathological research on the gills of carp (C. carpio) after being infected with E. tarda bacteria experienced stress, this was seen from the decreased total erythrocytes, increased total leukocytes, and there was considerable damage to the gill organs such as edema, fusion, and necrosis. The goldfish returned to their normal condition after being treated with tembelekan leaf extract. The best dose obtained after treatment was treatment D with a dose of 200 mg/L. The results of the clinical symptom study showed a change from an abnormal condition to a normal condition in carp after being treated. Tembelekan leaf extract contains predominant compounds such as flavonoids and alkaloids which can be useful as medicine for goldfish infected with E. tarda bacteria.