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Background: Recurrent aphthous ulcer is a disease with unknown etiology that’s mostly treated symptomatically and has no definite cure. Ayurveda an ancient medication system that was developed throughout the religious text times, around 5000 years ago. Berberis aristata have been used as medicinal herb due to its antimicrobial, antioxidant, anti-inflammatory, analgesic and healing effects, has been useful in treatment of oral aphthous. Material and Method: Therefore, we decided to formulate a Hydrogel with Berberis aristata bark extract to reduce the need for corticosteroid therapy in patients with oral ulcers. Hydrogel was formulated with central composite design using different concentrations of Carbopol 934 and Sodium carboxyl methylcellulose and evaluated for different parameters like pH, viscosity, spredability, drug content, gel strength, percent yield, drug release and antifungal activity. Result and Conclusion: The F1 batch was found to be optimized batch as its drug content was 95.58% and drug release was 67.15% and it was stable safe and effective for treatment of mouth ulcers.