Evaluation of antihyperlipidemic activity of leaves Salacia oblongifolia, Salacia reticulate, Lagerstroemia parviflora and their polyherbal mixture

Abstract

The study reveals the effects of different treatments on serum lipid parameters. The Hyperlipidemic Control group shows significantly elevated levels of total cholesterol, triglycerides, LDL-C, and VLDL-C compared to the Normal Control (Saline) group, indicating the presence of hyperlipidemia. Treatments such as MESO (400 mg/kg), MESR (400 mg/kg), and MELP (400 mg/kg) led to a reduction in lipid levels, with MELP showing notable decreases in triglycerides and VLDL-C. The PHME (400 mg/kg) group exhibited the most significant increase in HDL-C (p < 0.01), suggesting its potential to improve lipid profiles. Atorvastatin also effectively reduced triglycerides and VLDL-C, but had a lower impact on HDL-C compared to PHME. Overall, several treatments showed promising results in mitigating hyperlipidemia, with PHME standing out for its ability to raise HDL-C levels.