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Background: Various studies have reported poor health related quality of life (QOL) in females diagnosed with polycystic ovarian syndrome (PCOS) as compared to their healthy counterparts. Weight loss is the key component in management of PCOS and most often impact of PCOS on QOL is not addressed in these females. Aims: To develop a management strategy which can improve health related quality of life (QOL) in PCOS females. Methods and materials: 114 PCOS females were randomly divided into experimental group (n=57, exercise, diet counselling and Rajyoga meditation) and control group (n=57, diet counselling and Rajyoga meditation). Polycystic Ovary Syndrome Questionnaire (PCOS-Q) score was assessed before and after 12 weeks of interventions. Results- IBM SPSS Statistics 22.0 was used for analysis with two tailed p<0.05 statistically significant. Reduction in all 5 domains of PCOS-Q was statistically significant within both groups (pre-test and post-test, p<.05). Conclusions: The study shown statistically significant improvement in health related QOL in both the groups.