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A lack of iron progresses gradually through different stages. As evidenced by a decrease in the levels of hepatic non-heme iron in the newborns of iron deficient mothers, early iron shortage led to a depletion in iron reserves. The impact on the central nervous system, which results in deficiencies in human cognition and learning processes, is particularly significant. Strong evidence suggests that iron insufficiency is the primary cause of anaemia in many underdeveloped nations. Supplementation may, in some cases, but not always, prevent various iron deficiency-related abnormalities.