Antibacterial Response of Uncaria Gambir Leaves Extract and Ester Derivative of Catechol Against Periimplantitis Related Bacteria

Abstract

Bacteria related periimplantitis is a serious concern for the of dental implants failure. Evidences over S. aureus and E. coli to cause periimplantitis, antibacterial potential of Uncaria gambir and catechol motivated present study to compare the antibacterial activity of ester derivative of catechol (EDC) and Uncaria gambir leaves extract (UGLE) against periimplantitis related bacteria (PRB). Current study involved synthesis of EDC and preparation of UGLE. The EDC was characterized using ATR-IR, 1H-NMR and Mass spectrometric data. Both EDC and PRB were further investigated for their antibacterial activity against PRB that is Escherichia coli and Staphylococcus aureus. Among two, the EDC exhibited high antibacterial activity when compared with UGLE. Based on the results, present study concludes that EDC possess high antimicrobial potential against PRB and recommends that EDC should be further investigated to support its clinical significance.