A study of the antithyroid properties of Fragaria vescafruit extract using Male rats was conducted to investigate its antithyroid activity

Abstract

Background: A number of pharmacological agents are available for use as antithyroid agents. Fragaria vesca a plant extract widely available can be evaluate for its Antithyroid activity.

Methods: Fragaria vesca can be used as anti-inflammatory, anti-microbial, anti-allergic and anti-diabetic. This plants extract is also shown antithyroid activity. Hyperthyroidism induced rats were experimented by administering Thyroxine orally for 14 days. Hyperthyroid wistar male rats were treated with oral doses of 2 mg, 4 mg and 6 mg of Fragaria vesca extract for a period of 21 days. Methimazole 0.04% w/v for 21 days was used as the standard.

Results: This study had shown that T₃ and T₄levels successfully reduced with increase in the dose of Fragaria Vesca extract when compare to the standard Methimazole.

Conclusion: The antithyroid activity of Fragaria Vesca is clearly evident to decrease the levels of T₃ and T₄ levels. Further molecular studies can be conducted to determine the exact mechanism of action for its anti-thyroid activity.