In Silico Prediction of Mirna and Gene-Network Analysis of TTN Gene, A Key Regulator of Squamous Cell Neoplasms

Abstract

Introduction: Squamous all carcinoma (SCC) is the second most common form of skin cancer. It’s usually found in areas of the body damaged by UV rays from the sun or tanning beds. Titin is a protein that is found in humans and is enclosed by the TTN gene. Titin is a giant protein, greater than 1μM  in length, that functions as a molecular spring which is responsible for the passive elasticity of muscle. Predicting the targeted miRNA related to TTN in regulation of squamous cell neoplasm.

Materials and Methods: Gene network analysis of TTN was carried out by . STRING database where score of <0.99 considered. Target miRNAs predicted by miRDB prediction and target score 91 and alone considered.

Results and Discussion: TTN is highly oncogenic and is associated with many other genes and affects their activity when upregulated and downregulated. The TTN gene is highly expressed in the squamous cell neoplasms and helps in the proliferation and metastasis of the cancer. It’s overexpression had a positive correlation of growing tumors and neoplasms

Conclusion: TTN mutation may be associated with squamous all carcinoma and positively correlated and serve as potential indicator of squamous all cancer.