Protein – protein Interaction Mapping of Neurodegenerative Disease

Abstract

Significant health risks are associated with neurodegenerative disorders. A variety of age-related factors have developed recently with the increase in the older population. These illnesses are characterised by the accumulation of proteins with altered physicochemical properties and the progressive degradation of neurons in the peritoneal and brain tissues. Some of the most challenging issues that modern nations face as their populations get older are Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis. The four types of proteins that are involved in these illnesses are Huntingtin, Alpha-synuclein, Amyloid beta, and TAR DNA-binding protein of 43 kDa (TDP-43). Dopamine release and transport may be regulated by alpha-synuclein. Tau, a microtubule-associated protein, binds to STXBP1, a critical component of the synaptic vesicle exocytotic machinery, reducing caspase-3 activation potential function in synaptic vesicle exocytosis, which reduces neuronal sensitivity to various apoptotic events. The String database was used to identify protein-protein interactions between targets for neurodegenerative diseases that overlapped and were therefore considered to be potential targets. These disorders are linked to four different gene types: APBA2, TARDBP, HTT, and SNCA. Twenty possible neurodegenerative diseases were present in all.