3 Main Factors Influencing The Processes Of Growth And Development Of The Organism Of Laboratory Animals

Abstract

The study of the influence of extreme conditions (high air temperature, insufficient protein diet, benzene) on
the growth and development of the body of laboratory animals is an urgent problem in experimental
medicine. Purpose: to study the mechanism of the influence of adverse factors on the peri- and postnatal
periods of growth and development of laboratory rats, i.e. from birth to puberty. Methods: Studies were
carried out on white laboratory rats in the postnatal period of both sexes, weighing from 5.78 to 208.5 g. The
studied biochemical and morphological development indicators (body weight) in laboratory animals were
compared with those of the control group. The study of the effect of exposure to benzene, high air
temperature and insufficient amount of proteins in the diet at a dose of 112.0 mg/kg was carried out in the
prenatal and postnatal periods of development of the body of laboratory rats for 105 days. Results: Under the
influence of benzene, high air temperature and lack of protein in the diet, the growth of laboratory animals
significantly lagged behind those of the control group of laboratory animals that received a normal protein
content in the diet. A sharp decrease was observed from 21 and 28 days of age (by 6.4 and 12.2 g) - during
the transition from breastfeeding to artificial. Conclusions: Conducted experimental studies on the influence
of high air temperature, benzene, lack of protein in the diet, revealed a steady decline in the growth and
development of laboratory animals in the postnatal period.