Conceptualization And Assessment Of Herbal Tablet Containing Murraya Koenigii Using Linum Usitatissimum As Natural Binder.

Abstract

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and
metabolic abnormalities, often leading to insulin resistance and the development of Diabetes Mellitus (DM). This study
aimed to conceptualize and assess the efficacy of an herbal tablet formulation containing Murraya Koenigii, a traditional
medicinal plant known for its potential hypoglycaemic properties, with Linum usitatissimum (flaxseed) as a natural binder,
in reducing hyperglycaemia associated with DM in PCOS. A randomized, double-blind, placebo-controlled trial was
conducted on female participants diagnosed with PCOS and DM. The intervention group received the herbal tablet
formulation, while the control group received a placebo. The primary outcomes included changes in fasting blood glucose
levels, oral glucose tolerance test results, and glycated haemoglobin levels. Secondary outcomes included assessments of
insulin sensitivity, lipid profile, and anthropometric measurements. Safety and tolerability of the herbal tablet formulation
were also evaluated. The results of this study will provide valuable insights into the potential of the Murraya Koenigiibased herbal tablet with Linum usitatissimum as a natural binder, as an adjunct therapy for reducing hyperglycaemia in
PCOS patients with DM. This research contributes to the development of holistic treatment strategies for managing the
complex condition of PCOS-associated hyperglycaemia in individuals with DM.