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The limited efficacy of Imatinib as an anticancer agent is attributed to its significantly low solubility and its bioavailability issues. To prepare the cocrystals of Imatinib (IMB) using a cocrystallization techniques with the goal of improving the drug's physicochemical characteristics and bioavailability for myeloid leukaemia, some types of acute lymphoblastic leukaemia, and gastrointestinal stromal tumors. The preparations utilised the mechanochemical technique for two cocrystals of IMB with Theobromine (IMTH), and Alpha-ketoglutaric acid (IMKG). They were further characterised using a spectroscopic and thermoanalytical method. The DSC, PXRD, and FTIT techniques were used to characterize the newly obtained pure crystal forms. The crystal structure determination was done through PXRD, which revealed the presence of a triclinic crystal system having P-1 space groups. Allresults indicated that IMTH cocrystals possess better solubility and dissolution rate than parent drug. Thus, cocrystallization Thus, cocrystallization extends the scope of the existing preformulation choices prior to the pure API form to improve bioavailability and permeability.