ANTI-HYPERLIPIDEMIC ACTIVITY OF Hibiscus sabdariffa FLOWER BUDS IN TRITON-X100 INDUCED HYPERLIPIDEMIA IN RATS
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Abstract
The purpose :
The current study was planned to assess Anti-hyperlipidemic action of Hibiscus sabdariffa ehanolic flower buds extract in Triton X 100 induced Hyperlipidemia in Rats.
Mehod: Here Triton X-100 (100 mg/kg,i.p)induced Hyperlipidemia model is used.In this model the animals were divided into 5groups, in which 6 rats were used in each group. First group considered as , normal, 2nd control, 3rd as standard, 4th and 5th are considered as tested groups.In this method, Triton x-100 (100mg/kg)is induced to 4 groups except normal group. Rats in 4th and 5th groups were treated with an ethanolic flower bud extract of Hibiscus sabdariffa (EEHS) 200 and 400(mg/kg/p.o) for 7 days. On 8th day blood was collected by retro orbital sinus puncture,under mild ether anaesthesia.The collected blood samples were centrifuged for 10mins at 2000 rpm and serum samples collected were used for various lipid profile tests.
Results:
It is found that treatment with ethanolic flower buds extract of Hibisus sabdariffa (EEHS)essentially diminished the hyperlipidemia i.e diminished degrees of serum Total Cholesterol, Triglycerides, Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C) , and increment of serum High Density Lipoprotein Cholesterol (HDL-C) when contrasted with vehicle control and standard medication Atorvastatin (10 mg/kg).
Conclusion
The outcomes exhibited that ethanolic extract of Hibiscus sabdariffa buds had critical antihyperlipidemic action.