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The aim of the study was to evaluate the in-vivo antifungal activity of extracts of some plant species used in traditional medicine against various fungus spp. The plants were selected on the basis of their reported ethnobotanical uses and Minimal inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). We conclude from this that these extracts exhibit amazing fungicidal properties that support their traditional use as antiseptics. Plant extract was efficient at inhibiting the growth of C. albicans, in vivo. The results of fungal burden determination in the kidney at different time points, indicated a significant reduction in CFU/g in the tissue (p<0.05) starting from day 2 post-infection. Cell viability was significantly higher in mice kidney tissues treated with plant extract28 days post-infection. Histopathological analysis showed the presence of C. albicans between the tubules, as well as a few scattered lymphocytes and moderate congestion in the infected kidney 10 days post-infection. While in kidney section from mice treated with plant extract, mild congestion within the interstitial tissue was observed compared to Fluconazole treated groups.