The Synthesis and Characterization Of Several Heterocyclic Compounds Derived From Chalcone Derivatives, As Well As The Investigation Of Their Biological Activity

Abstract

In this work, 4-fluoro-3-methylacetophenone derivatives (1a-e) were prepared via aldol condensation with 4-fluoro-3-methylacetophenone and various aromatic aldehydes (a-e) in the presence of a base in ethanol to yield chalcones derivatives (1a-e), which are a valuable component for the synthesis of a wide variety of heterocyclic derivatives via reactions with hydrazine to yield pyrazole derivatives (2a-e), react with hydroxylamine hydrochloride to get isoxazole (3a-e), also react with urea to get oxazine derivatives (4a-e). All these compounds are characterized using FT-IR, ¹H-NMR, and mass, and follow reaction by TLC and measurements of melting points. After that, we analyzed the compounds' biological activity against two different types of bacteria.