Phytochemical And Pharmacological Screening Of Moringa Oleifera For Hepatoprotective Activity On Rats

Abstract

Moringa oleifera (M.oleifera) has been used as food and folk medicine to recover several diseases. In the present study is  effect of ethanolic extract of M.oleifera  on . Isoniazid and Rifampicin induced hepatotoxicity on rats. Isoniazid and Rifampicin was administered a 100 and 50 mg/kg bw dose to induced hepatotoxicity. M. oleifera (300 and 500mg/kg, p.o ) and Silymarin 100mg/kg, p.o. were administered once daily for 30 days. The degree of liver injury was estimated by liver function parameters ALP,AST,ALT,TP and TB. Isoniazid and Rifampicin drugs significantly increases in  serum ALP,AST,ALT,TP and TB and reduction in liver weight and changes in histopathology. Treatment with M.olefiera  extract significantly changing in weight liver and histopathology of liver as well as   Biochemical parameters in serum ALP,AST,ALT,TP and TB compare to control group. The biochemical parameters  and histopathology provide evidence that the ethanolic extract of M.oleifera has shown hepatoprotective activity.