Formulation and Evaluation of Momordica dioica Topical gel for Wound healing activity

Abstract

The aim of the present study is formulation and evaluation of Topical gel of  M. dioica for its physio-chemical properties in-vitro permeation and excision wound healing activity in rats. Topical gels were prepared by different two polymers Carbopol and Hydroxypropyl Methyl Cellulose (HPMC) in a range (0.5-1.5%). The gels were evaluated for their viscosity, spreadability, content uniformity, In-vitro diffusion of gels using Franz diffusion cell. It was observed that with an increase in the polymer percentage, there was a proportional increase in the viscosity and reduced spreadability. Similarly, the rate of diffusion of the drug from the gels was also reduced with an increase in the polymer concentration. All the prepared formulations demonstrated content uniformity and moderate to good spreadability. Treatment of M. dioica Topical gel on Excision wound  in rats significantly decreased wound contraction time and Percentage wound is compare to  control group. It concluded that M. dioica loaded Topical gels is a viable option for the treatment of wounds