Pharmacological Screening Of Ixora Coccinea For Hepatoprotective Activity

Abstract

Liver is the major organ which plays a key roles in metabolisms , biochemical ,physiological functions.  Ixora coccinea used Indian traditional Ayurvedic system of medicine for a variety of ailments. In the present study was evaluated effect of ethanolic extract of I. coccinea on Isoniazid and Rifampicin induced liver damage on rats. Isoniazid and Rifampicin was administered a 100 and 50 mg/kg bw dose to induced hepatotoxicity, I. coccinea 300 and 500mg/kg, p.o  and Silymarin 100mg/kg, p.o. were administered once daily for 28 days. The liver injury was estimated by liver profile parameters ALP,AST,ALT,TP and TB. Oxidative stress markers GSH, MPO,MDA,SOD  and CAT as well histopathology of liver. Inflammatory cytokines IL-6,IL-8 and TNF-α Isoniazid and Rifampicin drugs significantly reduction in liver weight,  increases in serum liver  biochemical, decreses in Oxidative stress, increases in Inflammatory cytokines levels and changes in histopathology of liver. Treatment with I. coccineain a dose depended manner significantly changing in weight liver, liver function estimation , lipid peroxidation, Inflammatory cytokines levels and histopathology of liver compare to control and Silymarin group. The present studies evidence that the ethanolic extract of I. coccinea has shown hepatoprotective effect