Synthesis, Structural, Thermal Studies And Biological Activity Of Schiff Base Transition Metal Complexes

Abstract

In order to obtain the Schiff base (1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide) ligand yields, guanidine and acetoacetic ester interacted. The ligand and its metal complexes are described using thermodynamic investigations (TG and DTA), 1H-NMR, 13C-NMR, UV, and FTIR. The IR spectra show that the ligand binds to the metal ions and behaves neutrally. The thermal behavior of these chelates shows that the anions and ligand molecules disintegrate in the second step after the hydrated complexes lose their water molecules of hydration in the first. The produced metal complexes were then put to the test against Salmonella typhi, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Listeria monocytogen, and Listeria candida for their antibacterial, antioxidant, and antidiabetic properties. The activity data indicates that the metal complexes are more effective against one or more bacterial species as antioxidants, antidiabetic agents, and antibacterial agents.