Identification Of Genetic Variants In AGT Gene With Association With Increased Blood Pressure And The Risk Of Hypertension.

Abstract

The present research provides extensive research on the variants of the angiotensinogen (AGT) gene, which plays an essential role in the risk factors related to cardiovascular medical conditions and hypertension. The AGT gene is used in our body to regulate blood pressure, and it also provides equilibrium to various fluids in the human body. This research aims to identify the common variants that play an essential role in cardiovascular medical conditions. This research also included identifying the impact the variants and their mutation might have on developing essential hypertension. Kurdi, De Mello, and Booz (2005, pp. 1357-1367) stated that the renin-angiotensin-aldosterone system (RAAS) is responsible for the etiology of hypertension. The findings of this research were the focus on the nine SNPs which founded in AGT gene tow SNPs present in exon number 2 named rs699 and rs4762 and in the untranslated region found five SNPs named rs5046, rs5049, rs11568020, rs5050, and rs5051. Finally, the intron contains two SNPs named rs2148582 and rs3789679. It determined that AGT genes help us better understand the functions and processes of the different variants. Several studies have found a connection between enhanced AGT gene variants causing an increase in hypertension and AGT plasma. The following research touches on various aspects of angiotensinogen AGT, its system, and its impact on various functions in our body.