Evaluation And In-Vitro Dissolution Study Of Clotrimazole By Solid Dispersion

Abstract

Clotrimazole, a medication with low water solubility, was formulated into solid dispersions utilizing polyethyleneglycol and various molecular weight polyvinyl pyrrolidones as carriers in varying weight ratios. Furthermore, binary and ternary b-cyclodextrin complexes were synthesized using various molar ratios. Solid dispersions and β-cyclodextrin complexes were both produced using the solvent evaporation approach. The impact of the carriers on clotrimazole's solubility in water was assessed using a phase solubility technique. All the preparations' dissolution was assessed using the USP paddle method. The solid dispersions and inclusion complexes were analyzed using differential scanning calorimetry and X-ray powder diffractometry to determine the impact of the carriers on reducing clotrimazole's crystallinity and forming complexes. After evaluating the physical characteristics and medication release behavior, polyvinylpyrrolidone solid dispersions and ternary cyclodextrin complexes were chosen as the best formulations for suppositories. Suppocire AM/50 mg carbopol 940 was selected as the suppository foundation, and the suppositories were made using the molding technique. The suppositories were analyzed for weight consistency, softening duration, and medication concentration. All these features were deemed optimal. The drug release pattern in an artificial environment was analyzed in citrate buffer with a pH of 4.5 and 1% sodium lauryl sulfate. Clotrimazole release from solid dispersions and inclusion complexes in suppositories was significantly enhanced compared to suppositories containing the intact medication. Suppositories containing solid dispersions of polyvinyl pyrrolidone exhibited outstanding antifungal properties