Effect Of Gut Microbiome On Immune Regulation Of Central Nervous System (CNS) In EAE Mouse Model

Abstract

The gut microbiome plays a crucial role regulating immune responses in the central nervous system (CNS). This study investigates the effect of the gut microbiome on immune regulation in a mouse model of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Using high-throughput sequencing techniques, we analyzed the composition of the gut microbiome in EAE mice and its impact on immune responses in the CNS. Our results demonstrate that alterations in the gut microbiome composition are associated with changes in the immune regulation of the CNS in EAE mice. These findings highlight the importance of the gut-brain axis in regulating immune responses in neuroinflammatory diseases.