Phytochemical Analysis And Anti-Nociceptive Activity Of Ethanolic Leaves Extract Of Crataeva Adansonii DC In Rodents

Abstract

Objective: The aim of this study was to screen the phytochemical constituents and evaluate the analgesic activity of crude ethanolic leaves extract of Crataeva adansonii at 50,100 and 200 mg/kg doses in experimental animal models.

Methodology: The ethanolic extract was prepared by maceration method followed by use of rotary evaporator. Phytochemical screening was done by using various tests. Analgesic activity was examined by acetic acid induced writhing for the evaluation of peripheral pain and tail flick and hot plate test were used for central pain evaluation. 

Result: Ethanolic leaves extract and diclofenac sodium showed significant activities in both central and peripheral analgesic models as compared to control (p<0.001). Although leaves extract at dose of 50 and 200 mg/kg showed extremely significant result than 100 mg/kg of Crataeva adansonii. It was noted that diclofenac sodium was more potent among all with significantly greater activities as compared to all doses (p<0.05).

Conclusion: Crataeva adansonii can be used as an effective drug in the treatment of peripheral as well as in central pain due to its promising activity in animal models.