Formulation And Characterization Of Mucoadhesive Tablets For Prolonged Drug Release

Abstract

This study focuses on the formulation and evaluation of atenolol mucoadhesive tablets, aiming to enhance drug absorption and bioavailability. Hypertension, affecting a significant portion of the adult population, can lead to severe cardiovascular conditions. Atenolol, a beta-blocker, effectively manages hypertension and other heart-related issues. The study used mucoadhesive polymers like hydroxypropyl methylcellulose (HPMC), tamarind gum, and badam gum to prepare the tablets via direct compression. The formulation process included optimizing drug release kinetics and mucoadhesive strength. Pre-compression parameters such as angle of repose, bulk density, and compressibility index were evaluated. Post-compression evaluations covered organoleptic properties, hardness, friability, weight variation, and in-vitro dissolution. Stability studies followed ICH guidelines to ensure long-term efficacy and safety. Key findings include consistent drug content, adequate hardness, and desirable swelling behavior. The optimized formulation demonstrated prolonged drug release and significant mucoadhesive properties, confirming its potential for improved therapeutic applications. Statistical analyses validated the formulation's consistency and reliability.