Formulation And Evaluation Of Mouth Dissolving Tablet Of Nitrendipine

Abstract

Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study two different methods direct compression and sublimation in formulation of mouth dissolving tablets of clozapine. Total nine formulations using various superdisintegrants agents were prepared. All prepared formulations were evaluated for physico-chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 25 to 35 s. In vitro cumulative percentage drug release for formulations prepared by direct compression with Doshion superdisintegrants shows 99.76% release in 15 min. Kinetic studies indicatedthat all the formulations followed first order release with diffusion mechanism.