Evaluation Of Paeonia Emodi For Their Antidepressants, Anticonvulsant And Antianxiety Activities

Abstract

Paeonia emodi, a medicinal plant used in traditional Himalayan medicine, has garnered interest for its potential therapeutic properties. This study aimed to evaluate the antidepressant, anticonvulsant, and anxiolytic activities of ethanol extract of Paeonia emodi roots using various preclinical models. The extract was tested for its effects on immobility in the Forced Swim Test and Tail Suspension Test to assess antidepressant-like activity, as well as its influence on seizure duration in PTZ, MES, and pilocarpine-induced seizure models for anticonvulsant effects. Additionally, anxiolytic activity was evaluated using the Elevated Plus-Maze, Hole Board Test, and Open-Field Test. Results indicated that the extract significantly reduced immobility time in both depressive models and extended latency to convulsion while reducing seizure duration in various seizure models. The extract also demonstrated anxiolytic-like effects by increasing time spent in open arms and head dipping in anxiety tests. These findings suggest that Paeonia emodi holds promise as a potential therapeutic agent for managing depression, anxiety, and seizures, supporting its traditional use and warranting further investigation into its active constituents and mechanisms of action.