Synthesis, Characterization And Biological Studies Of Metal (II) –Cinnamaldehyde-4,4’-Diaminodiphenylmethane

Abstract

A new Schiff base ligand was derived from the condensation reaction of Cinnamaldehyde and 4, 4’-diaminodiphenylmethane. Using this ligand the transition metal complexes Cu (II), Zn (II), Co (II) and Ni (II) were synthesized. The structural features of the synthesized compounds were confirmed by UV visible, NMR spectroscopic techniques and SEM. The thermal behavior of the metal complexes was determined by thermo gravimetric analysis (TGA). All the metal complexes were investigated for their anti oxidant and anti inflammatory activity. The metal complexes were tested the larvicidal activity against Culexquinquefaciatus. Anticancer activities were also studied towards human Osteosarcoma cells. Molecular docking also studied for the ligand and metal complexes. The obtained result showed that the complexes especially Cu (II) metal complex strongly active against cancer cells.