Antimicrobial Efficacy of Chitosan-Fused Silver Nanoparticles Against Human pathogens and Surface-Borne Pathogens

Abstract

Surface-borne pathogens pose a significant threat to public health due to their ability to persist on frequently touched surfaces and contribute to nosocomial and community-acquired infections. The present study investigates the synthesis, characterization, and antimicrobial efficacy of chitosan-fused silver nanoparticles (Ch-AgNPs) against a range of clinically relevant surface-borne bacteria, including Escherichia coli, Staphylococcus aureus, Micrococcus sp., Salmonella abony, Lactobacillus plantarum, Acinetobacter sp., and others. Results demonstrated that Ch-AgNPs exhibited superior antibacterial activity compared with standard chitin, extracted chitin, chitosan, and chito-oligosaccharides, indicating potential application in surface sanitation and biomedical coatings.