A Pilot Study on Nisha Triphaladi Yoga in Apatyanimittaja Madhumeha (Type 2 Diabetes Mellitus): A Single-Arm Pre–Post Quasi-Experimental Evaluation

Abstract

Background: Type 2 Diabetes Mellitus (T2DM), a common growing global health issue, inadequately controlled despite various advances in modern science or pharmacotherapy, which carries lacunae like side effect and long term dependency. Ayurveda correlates T2DM with Madhumeha, disorder with kapha-medo predominant, described under Ashta-Mahagada. Nisha Triphaladi Yoga is a classical formulation mentioned for Prameha, yet scientific evidence for its efficacy in early T2DM remains limited. This study aims to address this gap and evaluate its effect on subjective symptoms as well as RBS levels. Objective: Was to evaluate the effect of Nisha Triphaladi Yoga on subjective Ayurvedic parameters as well as Random Blood Sugar (RBS) in patients with T2DM. Methods: A single-arm interventional clinical study was conducted on 30 participants diagnosed with Apatyanimittaja Madhumeha. Nisha Triphaladi Yoga was administered for a period of 90 days. Assessment carried out was symptom grading (Bahumutrata, Atikshudha, Karapada Daha, Suptata) and RBS at baseline and after treatment. Data were analysed using paired t-tests and Wilcoxon signed rank test. Results: Marked improvement was observed among subjective symptoms. Bahumutrata reduced from 1.70 to 0.30 (p < 0.0001), Atikshudha from 1.65 to 0.30 (p < 0.0001) and Karapada Daha/Suptata from 1.65 to 0.35 (p < 0.0001). Mean RBS reduced from 227.00 mg/dl to 153.80 mg/dl (p < 0.0001). No adverse events were noted. Conclusion: Nisha Triphaladi Yoga demonstrated marked improvement in early-stage T2DM (Apatyanimittaja Madhumeha) with reduction in symptoms as well RBS ranges. Intervention was safe and well tolerated. Further larger controlled trials are needed in order to validate these findings.