ApoE Polymorphisms Rs(429358) and its association with ApoE enzyme and some Biochemical parameters in some of patients with Diabetic kidney disease

Abstract

The current study was designed to investigate the relationship of ApoE gene and its association with some lipids profile parameters in a sample of patients with Diabetic kidney disease.This study was conducted on (110) blood samples of people with Diabetic kidney disease, with (42) samples from healthy people as a control group. The results showed a non-significant increase in the level of enzyme (ApoE) (283.56 ± 14.98) in patients. when compared with healthy subjects. the results of the Real-Time PCR technique for the ApoE (rs 429358) gene in patients with diabetic nephropathy and healthy subjects were the presence of two alleles (T, C) and three genotypes (TT, TC, CC) and the frequency of the TT genotype was (0.527) and the value of (OR = 0.44 , 95% CI = 0.27 - 0.93) .The TC genotype is (0.3) and the CC genotype is (0.172). While the frequency of the two alleles C and T was (0. 66) for the T allele and the value of (OR = 0.647 , 95% CI = 0.69 - 1.01)  the C allele is (0.33) and the value of (OR = 1.97 , 95% CI = 1.8 - 4.37) .