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Deproteinization is the removal of proteins from a compound, typically as a step in chemical purification. In many processes for the chemical analysis of body fluids, it is a crucial step. Deproteinization can be used in dentistry to remove organic materials from the enamel surface prior to etching because it strengthens the orthodontic bond by primarily producing Type 1 and Type 2 etch patterns. Several writers have 5.25% sodium hypochlorite (NaOCl) was used to investigate with the effects of enamel deproteinization on the shear bond strength of various adhesive systems as well as the etching pattern. The various investigations on the efficiency of NaOCl as a deproteinizing agent, including its alternatives, have been examined and summarised in this article.