Antioxidant Effects of Resveratrol Against Cadmium Chloride in Albino Male Rabbits

Abstract

Several previous studies have been directed to find out the antioxidant effects of resveratrol against Cadmium chloride in many laboratories animals like rats and mice, the rabbits ( 12 rabbits ) were separated equally and randomly into 3 groups each group consist of 4 rabbits, the first group ( control group ) received a normal rabbit pellets, the 2^nd group ( Cd group) received orally by stomach tube 30 mg / kg of Cadmium twice weekly for 60 days, while 3^rd group (group Cd+ RES) administration orally by stomach tube 30 mg / kg of Cadmium twice weekly for 60 days, and after 1 hour administration orally by stomach tube 500 mg/ kg of resveratrol twice weekly for 60 days, the outcomes showed significant increase of Thiobarbituric acid reactive substances (TBARS) in 2^nd group while the superoxide dismutase & glutathione peroxidase showed significant decrease in 2^nd group, the results of pathological changes on lung in 2^nd group showed fibrosis, disruption of alveolar wall, emphysema, infiltration of inflammatory cells and collapse, not important lesions in 3^rd group.