The association of gluten-free diet with pentraxin-3 and lipid profile in Iraqi patients with celiac disease

Abstract

Aim: Estimated serum Pentraxine-3(PTX3) levels, Lipid profile, and BMI in Iraqi patients with celiac disease with and without GFD in order to validate their role in the exacerbation of celiac disease symptoms.

Method: One hundred Iraqi patients with celiac disease (aged from 20-55 years) were sign up in the current study. The Patients group were divided according to the period of the disease forP (n=48) (male=16, female=32) with a period less than one year and G (N=52) (male=24, female=28) with a period from (1-10 years) The G group was further subdivided in the form of G1 (gluten-free diet (GFD)=29) and G2 (non-gluten free diet (Non-GFD=23). Diagnosis is based on clinical examination. The Patients’ group matched with a control group (C, n=51) (male=25, female=26). Serum PTX3 and Lipid profile levels were resolute for each participant.

Results: The outcomes obtained from our study indicate a highly significant increase (p=0.000) in serum anti-TtG and PTX3 as compared with a control group. A significant increase was found in LDL, VLDL, and TG levels in G1 as compared with G2 and control groups while a significant decrease in BMI was found in G1 and G2 as compared to the control group.

Conclusion: High serum PTX3 are associated with CD with and without gluten free diet (GFD), while high serum LDL, TG and VLDL are associated with long life gluten free diet.