Histological study of endometrial hyperplasia for diabetic women in Erbil city

Abstract

Objective: Endometrial hyperplasia and type 2 diabetes mellitus (T2DM) may be correlated, but this is questionable. This investigation's goal is to evaluate T2DM's role in the emergence of endometrial hyperplasia.

Methods: Samples were collected from diabetic women over the age of 40 who had undergone a dilatation and curettage (D&C) operation after having their endometrial hyperplasia identified by ultrasonography. All samples underwent histological evaluation and p53, IL-6, and ER immunohistochemistry staining (estrogen receptors)

Results: Endometrium hyperplasia samples that underwent histological analysis showed bleeding, infiltration of inflammatory cells, and complex endometrial gland hyperplasia as a result of epithelial cell proliferation. The histological examination of endometrial hyperplasia in diabetic patients revealed significant differences in simple hyperplasia between samples with and without atypia. When the two hyperplasia groups were compared, it was found that there were significant variations (P˂ 0.05) in the gland area, stromal area, gland/stromal ratio, gland density, gland diameter, and epithelial height.

Conclusion: Diabetes is associated with both atypic and non-atypic endometrial hyperplasia, according to histological and immunohistochemical investigations. In diabetic hyperplasia with atypia as opposed to diabetic hyperplasia without atypia, there is a higher expression of ER, IL-6, and P53.