The relationship of IL-4, IL-10, and IFN-γ levels with infection by COVID-19 in Karbala city, Iraq.

Abstract

Coronavirus is considered one of the diseases arisen recently and ascending rapidly and the pathogenesis of the virus stays obvious via noticing the symptoms resemble that occurrence in the respiratory system. In current study showed the levels of cytokines in patients' serum that related to infection of COVID-19 where the samples serum were collected from the person volunteers who classify into three groups rely on cases of infection as severe or acute, moderate, and persons healthy recovered after infection of coronavirus disease, these cases were about (n = 100) also cases of normally considered control group, measured patients serum concentrations of some cytokines such as IFN-γ, IL-4, IL-10, by utilize the immune assay, enzyme-linked immunosorbent assays (ELISA). This study showed lower levels significantly of IL-4 and IFN-γ in the group of healthy recovered than in a group with severe cases of the disease, while IL-10 level in the group of healthy recovered was significantly higher than in a group of severe cases with coronavirus disease, also the current study referred to different levels of cytokines in all groups compared with a group of control, these variables may be related to the response of immune systems.