The influence and assessment of E-cadherin sera levels with periodontitis and gingivitis

Abstract

Periodontal disease occurs as a result of microorganisms and inflammation derived from the host, which is considered the main reason to teeth loss worldwide. E-cadherin is a protein present in the tissue of the gingiva that acts as a barrier against bacteria, so it is necessary to find it in the normal range, and their deficiency facilitates the entry of bacteria and other organisms penetrability to the tissue. The present study aims to investigate the possibility of using E-cadherin (E-cad) protein as a new marker for the diagnosis and progression of periodontal disease. This study was conducted at the University of Baghdad, College of Dentistry, Department of Periodontics, in the Periodontics clinic received 80 new patients 40 gingivitis cases, and 40 periodontitis. Periodontal parameters were measured for every patient. In order to assess the level of E-cadherin & vitamin C, and Ca2+.The result showed that significantly increased levels of E-cad in patients with Periodontal disease & vitamin C levels were significantly decreased in periodontitis & gingivitis patients compared with a control group. In conclusion, high levels of E-cadherin found in periodontal disease patients may be assessed and used as a marker for diagnosis and progression of the disease, vitamin C & Ca2+ deficiency is considered a risk factor for periodontal disease.