Protective activity of ferulic acid on rotenone-induced Neurodegeneration in Zebra-fish model

Abstract

Back ground- Parkinson disease is acknowledged as progressive disorder that cause degeneration of a neuron which occur as a result of abnormal cluster of a protein termed as alpha-synuclein that leads to a diminishing effect to the level of brain dopamine level in basal ganglia. Methods and Materials determine the behavioral parameter, dopamine and catalase level and mitochondrial function of Rotenone induced zebra fishes we carried out an experiment on 40 fishes induced with Rotenone (Parkinson inducer) and 10 normal fishes. Result -this article provides an inclusive, general and practical experimental procedure on zebra fish using Ferulic acid as our test compound and it act as anti-Parkinson phytochemical. Conclusion-we noticed that while the fish treated with Rotenone shows unusual feature like erratic movement and being in cataleptic state after some time and decrease on their Dopamine, Catalase and Mitochondrial function level, on the other hand the fish that was priorly treated with Ferulic acid followed by a direct exposure to Rotenone shows an increasing level of bio chemical parameter.