Promising histological and functional effects of asparagus officinalis L. roots extract on letrozole induced polycystic ovary syndrome in female rat‏

Abstract

Polycystic Ovarian Syndrome A variety of symptoms, including metabolic and endocrine abnormalities, hirsutism hyperandrogenism, amenorrhea, anovulation, and sterility, describe. The goal of the current study is to assess how well an extract from the roots of Asparagus officinalis L. can treat female rats with induced polycystic ovarian syndrome when different hormonal levels are present. Female rats were given daily doses of letrozole 1 mg/kg for 28 days in order to produce PCOS. Asparagus officinalis 400mg/kg was administered to the rats after PCOS was induced, and the hormonal parameters were examined after 28 days, Roots of Asparagus officinalis L. were used as a conventional pharmaceutical beside that its treatment and preventive role, In the therapy group compared to the PCOS group, there was a discernible rise in primary, antral, and graphene follicles, Compared to the PCOS group, the treatment and preventative groups had less cystic follicles, Moreover, compared to the control group and other groups, PCOS shows a large rise in testosterone and LH levels and a considerable decline in estradiol and FSH levels, When compared to control and other groups, the conventional medicine made from asparagus roots significantly increased levels of estradiol and FSH while significantly decreased levels of testosterone and LH were seen, Moreover, a rise in the number of ovarian follicles is seen. Conclusion: asparagus officinalis L. roots extract improved the endocrine hormones and the histomorphometric features of the ovary in the Treatment group.