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Atherosclerotic heart disease, heart attacks, and stroke are major complications of hyperlipidemia, but atherosclerosis is the main killer. Medicinal plants are the primary source of sickness treatment in underdeveloped nations. Sesbania grandiflora is produced in its natural environment, making it more readily available, cost-effective, and side-effect-free locally. In order to evaluate the anti-hyperlipidemic activity of methanolic extracts of Sesbania grandiflora in triton X-100 induced hyperlipidemic rats of the respective extracts, it was taken into account that Sesbania grandiflora is beneficial in the metabolism of cholesterol. The results showed that this plant exhibits hyperlipidemic activity and also exhibits minimal side effects towards the liver and cardiac muscle tissues.