The relation of some hematological parameters in Toxoplasma gondii infection associated with myocarditis

Abstract

Background: Toxoplasmosis is an infective disease that originates from zoonotic transmission and is most dominant in countries with low socio-economic nations. Humans can acquire the disease via the consumption of infected food that contains the parasite oocyst or through the ingestion of the parasite tissue cyst in raw or undercooked meat. This study was designed to evaluate the seroprevalence of T. gondii in myocarditis patients and the alterations in some common hematological parameters and other inflammatory and cardiac biomarkers.

Materials and methods: The study was carried out in Kirkuk Governorate from March 2022 to June 2022, blood specimens were extracted from 45 myocarditis patients diagnosed on clinical bases at Azadi Teaching Hospital-cardiopulmonary resuscitation ward and 45 healthy control. Patients and control serum were assessed for Toxoplasma IgM, IgG quantitative and ELISA, Haematological investigation and infectious biomarkers like (CRP, myoglobin and Procalcitonin (PCT) tests were also conducted on the patients and control groups.

Results: The data recorded significant increment in cardiac markers including CRP, myoglobin and PCT test, with P= 0.0012, 0.001, and 0.001 respectively. In addition, a significant data was recorded in gender regarding IgG level P=0.0038.

Conclusions: The study concluded that toxoplasma screening in myocarditis patients could provide a clue of the presence of infection and the haematological as well as the other inflammatory markers may help in monitoring active toxoplasma infection.