Design, Synthesis, and Characterization of New mono, diPeptide Prodrugs, and their Bioactivity

Abstract

The synthesized two new derivatives of mono peptide H1, (Synthesis of monoPeptide (levofloxacin acid chloride with glutamine ), and dipeptide H5 (Synthesis of diPeptide (The Boc-d-3,3-diphenylalanine acid chloride (Boc-d-3,3-DPAAC), using a Levofloxacin substituted. Spectroscopic data were characterized as well as reactivity indices by using techniques FT-IR,  ¹H-NMR, and ¹³C-NMR. The bioactivity was studied for two derivative compounds H1 and H5 against three types of gram-positive and three types of gram-negative Bacteria, the derivatives of levofloxacin have appeared excellent results against these Bacteria.