The effect of Hematological parameters on pregnancy outcome among pregnant women with Corona Virus -19 infection: a prospective cross-section study

Abstract

Coronavirus Disease 2019 (COVID-19), emerged in early December 2019 in China and became a pandemic situation worldwide by its rapid spread to more than 200 countries or territories. The prevalence and evolution of COVID-19 in pregnancy, including the risk of miscarriage in the first and second trimester and early preterm birth. So we need to identify the laboratory parameters capable of discriminating between severe and non-severe cases, or those at high or low risk of abortion, the present study aims to highlight the role of hematological markers (ferritin, D-dimer, CR Protein, ESR, LDH, Random Blood Sugar, hemoglobin, white blood cell & albumin) each one has a role in the development of signs and symptoms.  Blood samples were collected from 47 newly diagnosed pregnant women with  COVID19 in Najaf-Iraq from June 13 to October 06, 2020.  Then the cases followed up for 200 days (two trimesters) about 13 pregnant women aborted before reach to the second trimester, the  ANOVA and Kaplan-mier test shows a significantly high level of ( ferritin, D-dimmer, CRP, ESR, RBS, and LDH ) correlated with abortion and increased rate of loss baby and vice-versa occurs among 34 pregnant women who successfully passed to second trimester,(P<0.005,0.014,0.003,0.005,0.005&0.001respectively), Meanwhile the elevated levels of hemoglobin and albumin correlated with a high chance of saving pregnancy period (P< 0.002, 0.001respectively). also, the result shows there is no significant effect of lymphocyte concentration during the pregnancy period in pregnant women with COVID19. From these findings, we can conclude that the changes of hematological parameters correlates with the saving or losing the baby during pregnancy and may help in control the severity of COVID19 infection by using these markers as the prognostic marker