Polyethylene Oxide(PEO) as antibacterial activity against Azo Days Bacterial Isolates with clinical application

Abstract

Background: Poly ethylene oxide (PEO) is a non - linear system hydrophilic and uncross linked polymer with a variety of molecular weights. Ethylene oxide is used to make it, and it offers a number of beneficial characteristics for medication delivery and antibacterial uses. PEO is effectively integrated into amorphous calcium phosphate (ACP) during its synthesis, it is predicted to influence ACP's inclination to form aggregates.

Methodology: In the present study, polyethylene oxide (PEO) with different concentration ‘(80, 40, 20, 10 μg/ml)’ investigates their antibacterial activity, against five pathogenic bacteria isolated from azo dye (random selection from total isolates). The disk diffusion test was used to evaluate the antimicrobial activity of PEO, as In addition, each isolate's ‘minimum inhibitory concentration (MIC)’ and ‘minimum bactericidal concentration (MBC)’ were determined.

Results: PEO exhibits strong broad-spectrum antibacterial action against tested bacteria, with an inverse relationship between an increase in ‘inhibition zone diameter’ and a decrease in PEO concentration, and even outperforms the action of certain medicines. PEO had ‘MICs of 10 to 20 g/ml and MBCs of 20 to 80 g/ml’. PEO was shown to be firmly adhered to bacterial cells in other experiments, its inhibitory impact on bacterial growth and invasion might be attributed to this factor.

Conclusion: The bacterial growth was considerably inhibited by PEO at a suitable concentration. It is strongly suggested that PEO be used as a cost-effective antibacterial agent, particularly when mixed with dyes used at home or in industries, to avoid the possibility of creating antibiotic-resistant bacterial strains.PEO has a good effect on filer and composite properties like ACP.