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Acute exposure - as a result of prolonged low-frequency exposure to ionizing radiation, radiation sensitivity of organs develops to varying degrees. It has been established that atrophic and sclerotic changes in the organs of the immune system (spleen, lymph nodes, malt and salt structures, bone marrow and thymus) develop under acute irradiation. Organs with low sensitivity to radiation - kidneys, liver, lungs, tissues. In acute irradiation, organs are damaged in the same way as when exposed to a thermal factor. It has been established that an increase in vascular permeability, cellular hypoxia and metabolic disorders lead to stimulation of the synthesis of fibroblast tropocollagen, sclerotic changes in organs and atrophy of parenchymal elements.